Used 2021 Mercedes-Benz S-Class for Sale near Sebring, FL
181 results
CarGurus Analysis:
2021 Mercedes-Benz S-Class
With 804 currently listed for sale and an average price of $61,412.00, 32.3% of 2021 Mercedes-Benz S-Class vehicles for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 5 / 5 stars.
85.3% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a redesigned infotainment system, powerful engine options, and advanced driver-assist technologies, along with a luxurious interior that enhances comfort and tech integration.
CarGurus Analysis: 2021 Mercedes-Benz S-Class
overall
Summary
With 804 currently listed for sale and an average price of $61,412.00, 32.3% of 2021 Mercedes-Benz S-Class vehicles for sale on CarGurus are rated as good or great deals.
Favorably reviewed: Owners rated the 2021 Mercedes-Benz S-Class 5 / 5 stars.
85.3% of 2021 S-Class models on CarGurus are accident free.
The 2021 Mercedes-Benz S-Class features a redesigned infotainment system, powerful engine options, and advanced driver-assist technologies, along with a luxurious interior that enhances comfort and tech integration.
Why it stands out
The 2021 Mercedes-Benz S-Class excels in the luxury sedan market, combining powerful engine options with cutting-edge technology and unparalleled comfort. Available in two configurations, the S500 4Matic and S580 4Matic, it features advanced powertrains, including a 3.0-liter inline-six and a 4.0-liter twin-turbo V8 that deliver impressive performance. The interior is a blend of sophistication and tech, highlighted by a minimalist design that includes a massive OLED touchscreen and extensive ambient lighting. Although some users have noted issues with the run-flat tires, the overall feedback reflects a very positive reception, making it a desirable choice for those seeking luxury and innovation.
Other model years to consider
- Average price: $66,168.00
- Good/great deal percentage: 31.4%
- User rating: 4.8 / 5
- Total listings: 1,089
- Average price: $25,643.00
- Good/great deal percentage: 31.5%
- User rating: 4.88 / 5
- Total listings: 956
- Average price: $21,743.00
- Good/great deal percentage: 31.1%
- User rating: 4.89 / 5
- Total listings: 792
This analysis is based on CarGurus' proprietary market data from March 30, 2026, CarGurus experts' opinions, and generative AI.
Relevant articles
The Best Sedans of 2026
As more people flock to SUVs and crossovers, some automakers are killing off sedans. But others are doubling down, building some of the best four-door cars we’ve ever driven. For a supposedly dying segment, the sedan market looks awfully healthy.
2026 Mercedes-Benz S-Class Pricing, Specs, and Release Date
Mercedes-Benz avoids drastic change with the 2026 S-Class sedan and instead refines the lineup with updated packages and configurations, plus a host of new paint colors and interior treatments.
Who Makes Maybach Cars?
Maybach is a German luxury brand, that currently offers extremely upscale cars and SUVs. It was once a standalone brand, then a division of Mercedes-Benz. Today its vehicles are ultra-high-end versions of existing Mercedes-Benz models.
5.0 Overall rating
Filter by rating
Chris V
Reviewed a 2021 Mercedes-Benz S-Class on Jun 5, 2024
This car is a driving experience like no other, power, luxury, amenities. I own a dozen cars from square body trucks, sports cars to Cadillacs, this is unrivaled in its ride. I cant wait to get in it each day.
Deno P
Reviewed a 2021 Mercedes-Benz S-Class on Mar 23, 2023
This car is the ultimate in form and function. It is engineered to exacting performance standards to operate in its pure intent as an automobile to get from point A to B. But it has state of the art exquisite technology and appointments that are so mind blowing that you would drive right past B headed to Z. Performance, comfort and luxury at is best is what this car is.
Rob G
Reviewed a 2021 Mercedes-Benz S-Class on Feb 25, 2022
Full of technology. Easy learning curve. Handles beautifully. Acceleration makes you giggle.
James B
Reviewed a 2021 Mercedes-Benz S 580 Sedan 4MATIC on Oct 14, 2024
The car is loaded with luxuries , very stylish at the same time sporty. You get a lot of car for the money and they hold there value. BMW would be close cusin to Mercedes.
2021 Mercedes-Benz S-Class Trims
| Trim type | MSRP |
|---|---|
| AMG S 63 Cabriolet 4MATIC | $185,400 |
| Maybach S 580 Sedan 4MATIC | $184,900 |
| S 560 Cabriolet RWD | $140,000 |
| AMG S 63 Coupe 4MATIC | $173,100 |
| S 500 Sedan 4MATIC | $109,800 |
| S 560 Coupe 4MATIC | $131,400 |
| S 580 Sedan 4MATIC | $116,300 |
2021 Mercedes-Benz S-Class Price Trends
CarGurus tracks the prices of millions of used car listings every year. See how the average price of 2021 Mercedes-Benz S-Class prices has changed over time.
See more price trends
