The 2007 Toyota Sienna receives several upgrades, including a more powerful engine. CD changers and satellite radio capability are added to all models, as is a new tire pressure monitoring system.
There are seven Sienna variations offered for 2007, due to the availability of four trims and two drive trains. The CE is the entry point for the Sienna line. AWD is not available with this trim, but seven and eight seat configurations are. The CE comes equipped with dual sliding doors, front and rear air conditioning, a six speaker audio system, keyless entry, and full power accessories. The LE adds the AWD option, along with a roof rack, tinted glass, cruise control, and an in-dash CD changer. The XLE is equipped with power lift gate and rear doors, power front seats, and tri-zone climate control. The premium XLE Limited trim finishes the Sienna with 17 inch wheels, a moon roof, leather, a JBL audio upgrade with ten speakers, and xenon headlights. Adding AWD to all trims will also equip the Sienna with run-flat tires, 17 inch wheels, and a windshield wiper de-icer. Options are assembled in packages, and availability of add-ons increases with the price. The XLE and XLE Limited models are eligible for a DVD-based navigation system with Bluetooth and a rear backup camera, and a rear seat DVD entertainment system. All models share the same engine and transmission. The Sienna is now powered by a more potent 3.5 liter DOHC V-6, which generates 266 horsepower and 245 pound-feet of torque. All models include a towing preparation kit, which allows the minivan to pull 3500 pounds. The Sienna has an EPA rating of 19/25 mpg with 2WD, and 18/23 mpg with AWD.

The Sienna is the only minivan from the major manufacturers (Dodge, Nissan, Ford, Honda..) that offers AWD.