Year 2010 RX350 radio mode changes by itself

If the leak is fixed buy a new radio.

or remove the radio and dry it out.

Windshield was replaced around 2 years back. I don’t think water is still there

I don’t think anything wrong with the radio because leak was not, where the radio is. It may be wiring or computer or something else at that place. The water was leaking from the top corner of the window and it was going down in car thorough channel ( where the airbag is located and it covered with the plastic cover) (it is exactly the area between windshield and driver’s door). Water was not visible because it was traveling behind the plastic cover. Cover is attached to instrument panel, so the water was going there.

You can find more how to set and remove radio in Lexus RX 350 here: https://windupradio.com/set-radio-stations-in-lexus-rx-350/

My 2010 rx350 radio used to do this all the time. I banged on it with my fist right underneath the push start button to the left of the radio a few times and the problem went away. Every few months it comes back, I just hit that same spot once or twice and it stops. Most interesting car I've ever driven.