Used 2021 Mercedes-Benz S-Class for Sale near Houston, TX

## Summary - With 152 currently listed for sale near Houston, TX and an **average price of $60,945.00**, 16.4% of 2021 Mercedes-Benz S-Classes for sale on CarGurus are rated as good or great deals. - **Favorably reviewed:** Owners rated the 2021 Mercedes-Benz S-Class 5 / 5 stars. - **83.6% of 2021 S-Class models on CarGurus are accident free**. - The 2021 Mercedes-Benz S-Class features a sophisticated infotainment system, luxurious interior materials, and impressive performance from its powertrains. ## Why it stands out The 2021 Mercedes-Benz S-Class embodies luxury and performance, combining a striking design with advanced technology. This model marks a significant overhaul from its predecessor, improving both comfort and technology features. The S-Class is available in two configurations: the S500 with a 3.0-liter inline-six engine delivering 429 horsepower and the S580 equipped with a 4.0-liter V8 producing 496 horsepower. Both versions incorporate a mild-hybrid system for enhanced efficiency. Notably, the model offers an enhanced air suspension and the first with rear-wheel steering, granting it superior agility despite its size. Inside, the S-Class is designed with the utmost attention to detail, featuring a spacious cabin adorned with Nappa leather and high-quality finishes. Technological advancements include a sophisticated infotainment system with a stunning 12.8-inch OLED touchscreen and an optional Burmester audio system with 30 speakers. Although luxuriously equipped, it does come at a high price, but many buyers find its features and overall driving experience justified. ## Other model years to consider - **[2022 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2022-Mercedes-Benz-S-Class-Houston-c31858_L34369)** - Average price: $66,859.00 - Good/great deal percentage: 14.1% - User rating: 4.8 / 5 - Total listings: 199 - **[2018 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2018-Mercedes-Benz-S-Class-Houston-c27088_L34369)** - Average price: $32,988.00 - Good/great deal percentage: 21.4% - User rating: 4.76 / 5 - Total listings: 182 - **[2015 Mercedes-Benz S-Class](https://www.cargurus.com/Cars/l-Used-2015-Mercedes-Benz-S-Class-Houston-c24430_L34369)** - Average price: $26,194.00 - Good/great deal percentage: 16.5% - User rating: 4.88 / 5 - Total listings: 194 This analysis is based on CarGurus' proprietary market data from March 19, 2026, CarGurus experts' opinions, and generative AI.