The 1976 Blazer featured a complete redesign, which resulted in a safer ride. A new roll-bar was fully integrated into a steel half-cab. A removable fiberglass and plastic roof was available as an option, and could be attached to the pickup bed.

The base engine remained a 250-ci I6 rated at 100 horsepower at 3600 rpm. Available engines included the reincarnated 305-ci V8 rated at 130 horsepower, a 350-ci V8 rated at 160 horsepower, and a 400-ci V8 rated at 175 horsepower.

Almost 75,000 Blazers were produced in 1976, their biggest production year to that point.